Targeted enhancement of cortical-hippocampal brain networks and associative memory

The influential notion that the hippocampus supports associative memory by interacting with functionally distinct and distributed brain regions has not been directly tested in humans. We therefore used targeted noninvasive electromagnetic stimulation to modulate human cortical-hippocampal networks a...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2014-08, Vol.345 (6200), p.1054-1057
Main Authors: Wang, Jane X., Rogers, Lynn M., Gross, Evan Z., Ryals, Anthony J., Dokucu, Mehmet E., Brandstatt, Kelly L., Hermiller, Molly S., Voss, Joel L.
Format: Article
Language:English
Subjects:
Adult
Association
Associative memory
Brain
Female
Hippocampus
Hippocampus - physiology
Humans
Information flow
Information processing
Information Transfer
Magnetic Resonance Imaging
Male
Memorization
Memory
Memory - physiology
Nerve Net - physiology
Networks
Neurobiology
Parietal Lobe - physiology
Stimulation
Transcranial Magnetic Stimulation
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The influential notion that the hippocampus supports associative memory by interacting with functionally distinct and distributed brain regions has not been directly tested in humans. We therefore used targeted noninvasive electromagnetic stimulation to modulate human cortical-hippocampal networks and tested effects of this manipulation on memory. Multiple-session stimulation increased functional connectivity among distributed cortical-hippocampal network regions and concomitantly improved associative memory performance. These alterations involved localized long-term plasticity because increases were highly selective to the targeted brain regions, and enhancements of connectivity and associative memory persisted for ~24 hours after stimulation. Targeted cortical-hippocampal networks can thus be enhanced noninvasively, demonstrating their role in associative memory.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1252900