Functional and Histological Assessment of an Experimental Model of Takotsubo's Cardiomyopathy

Background Our objectives were to characterize functional and structural features of an experimental model of Takotsubo cardiomyopathy, and its response to beta‐blockers. Methods and Results In protocol 1, a dose‐finding study: 69 rats received various doses of isoproterenol (ISO) and echocardiograp...

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Bibliographic Details
Published in:Journal of the American Heart Association 2014-06, Vol.3 (3), p.e000921-n/a
Main Authors: Sachdeva, Jaspreet, Dai, Wangde, Kloner, Robert A.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Echocardiography
electron microscopy
Fibrosis
Heart - physiopathology
Hemodynamics
histopathology
isoproterenol
Male
Metoprolol - pharmacology
Microscopy, Electron
Myocardium - pathology
Myocardium - ultrastructure
Necrosis
Original Research
Propranolol - pharmacology
Rats
Rats, Sprague-Dawley
Takotsubo cardiomyopathy
Takotsubo Cardiomyopathy - chemically induced
Takotsubo Cardiomyopathy - diagnostic imaging
Takotsubo Cardiomyopathy - pathology
Takotsubo Cardiomyopathy - physiopathology
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Summary:Background Our objectives were to characterize functional and structural features of an experimental model of Takotsubo cardiomyopathy, and its response to beta‐blockers. Methods and Results In protocol 1, a dose‐finding study: 69 rats received various doses of isoproterenol (ISO) and echocardiographic and histologic parameters were measured on days 2 to 3 or day 8. There were no dose‐dependent effects and, out of 69 ISO‐treated rats, 40 (58.0%) survived and 29 (42.0%) died within 24 hours. Of survivors, 30 had apical akinesis averaging 12.1±1.6% of the long axis LV circumference. Out of the 40 survivors, 32.5% showed apical akinesis ≥10%, 42.5% showed akinesis
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.114.000921