Loading…

Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats

•DBS of the accumbens shell attenuates cue-induced reinstatement of cocaine seeking.•DBS of the accumbens shell attenuates cue-induced reinstatement of sucrose seeking.•DBS of the accumbens shell non-selectively reduces cue-induced reward seeking behavior. Stimuli previously associated with drug tak...

Full description

Saved in:
Bibliographic Details
Published in:Behavioural brain research 2015-03, Vol.281, p.125-130
Main Authors: Guercio, Leonardo A., Schmidt, Heath D., Pierce, R. Christopher
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•DBS of the accumbens shell attenuates cue-induced reinstatement of cocaine seeking.•DBS of the accumbens shell attenuates cue-induced reinstatement of sucrose seeking.•DBS of the accumbens shell non-selectively reduces cue-induced reward seeking behavior. Stimuli previously associated with drug taking can become triggers that can elicit craving and lead to relapse of drug-seeking behavior. Here, we examined the influence of deep brain stimulation (DBS) in the nucleus accumbens shell on cue-induced reinstatement of cocaine seeking, an animal model of relapse. Rats were allowed to self-administer cocaine (0.254mg, i.v.) for 2h daily for 21 days, with each infusion of cocaine being paired with a cue light. After 21 days of self-administration, cocaine-taking behavior was extinguished by replacing cocaine with saline in the absence of the cue light. Next, during the reinstatement phase, DBS was administered bilaterally into the nucleus accumbens shell through bipolar stainless steel electrodes immediately prior to re-exposure to cues previously associated with cocaine reinforcement. DBS continued throughout the 2h reinstatement session. Parallel studies examined the influence of accumbens shell DBS on reinstatement induced by cues previously associated with sucrose reinforcement. Results indicated that DBS of the nucleus accumbens shell significantly attenuated cue-induced reinstatement of cocaine and sucrose seeking. Together, these results indicate that DBS of the accumbens shell disrupts cue-induced reinstatement associated with both a drug and a natural reinforcer.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2014.12.025