Global methylation silencing of clustered proto‐cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV

Epigenetic remodeling of cell adhesion genes is a common phenomenon in cancer invasion. This study aims to investigate global methylation of cell adhesion genes in cervical carcinogenesis and to apply them in early detection of cancer from cervical scraping. Genome‐wide methylation array was perform...

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Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2015-01, Vol.4 (1), p.43-55
Main Authors: Wang, Kai‐Hung, Lin, Cuei‐Jyuan, Liu, Chou‐Jen, Liu, Dai‐Wei, Huang, Rui‐Lan, Ding, Dah‐Ching, Weng, Ching‐Feng, Chu, Tang‐Yuan
Format: Article
Language:English
Subjects:
Adult
Antimetabolites, Antineoplastic - pharmacology
Azacitidine - pharmacology
Biomarkers
Biomarkers, Tumor - genetics
Breast
Cadherins
Cadherins - genetics
Cancer biomarker
Cancer Research
Carcinogenesis
Cell adhesion
Cell adhesion & migration
Cell Adhesion - genetics
Cell Line, Tumor
Cervical cancer
clustered proto‐cadherin
CpG Islands
Deoxyribonucleic acid
Diagnosis
Disease Progression
DNA
DNA methylation
DNA Methylation - drug effects
Endometrium
Epigenetics
Female
Gene Silencing
Genes
Genetic Loci
Genomes
HPV
Human papillomavirus
Humans
Inflammation
Middle Aged
Multigene Family
Neoplasm Invasiveness
Neoplasm Staging
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Severity of Illness Index
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - genetics
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Summary:Epigenetic remodeling of cell adhesion genes is a common phenomenon in cancer invasion. This study aims to investigate global methylation of cell adhesion genes in cervical carcinogenesis and to apply them in early detection of cancer from cervical scraping. Genome‐wide methylation array was performed on an investigation cohort, including 16 cervical intraepithelial neoplasia 3 (CIN3) and 20 cervical cancers (CA) versus 12 each of normal, inflammation and CIN1 as controls. Twelve members of clustered proto‐cadherin (PCDH) genes were collectively methylated and silenced, which were validated in cancer cells of the cervix, endometrium, liver, head and neck, breast, and lung. In an independent cohort including 107 controls, 66 CIN1, 85 CIN2/3, and 38 CA, methylated PCDHA4 and PCDHA13 were detected in 2.8%, 24.2%, 52.9%, and 84.2% (P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.335