Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis

N-methyl-d-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients ref...

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Bibliographic Details
Published in:British journal of psychiatry 2015-02, Vol.206 (2), p.164-165
Main Authors: Beck, Katherine, Lally, John, Shergill, Sukhwinder S., Bloomfield, Michael A. P., MacCabe, James H., Gaughran, Fiona, Howes, Oliver D.
Format: Article
Language:English
Subjects:
Adult
Aged
Antipsychotic Agents - therapeutic use
Autoantibodies - blood
Autoantibodies - immunology
Drug Resistance
Female
Humans
Male
Middle Aged
Psychotic Disorders - blood
Psychotic Disorders - drug therapy
Psychotic Disorders - immunology
Receptors, N-Methyl-D-Aspartate - immunology
Short Report
Young Adult
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Summary:N-methyl-d-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.113.142216