Performance of the Liaison XL Murex HIV Ab/Ag test on clinical samples representing current epidemic HIV variants

Screening for HIV infection has improved since the first immunoassays. Today, diagnosis of HIV infection can be performed with fourth-generation tests that track both the patient's antibodies and HIV antigen. The objective of this study was to evaluate the clinical sensitivity and specificity o...

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Bibliographic Details
Published in:Journal of clinical microbiology 2014-09, Vol.52 (9), p.3277-3279
Main Authors: Lemee, Véronique, Leoz, Marie, Etienne, Manuel, De Oliveira, Fabienne, Plantier, Jean-Christophe
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Child
Child, Preschool
Diagnostic Tests, Routine - methods
Epidemics
Female
HIV Antibodies - blood
HIV Antigens - blood
HIV Infections - diagnosis
HIV Infections - epidemiology
HIV-1 - immunology
HIV-2 - immunology
Humans
Infant
Male
Mass Screening - methods
Middle Aged
Sensitivity and Specificity
Virology
Young Adult
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Summary:Screening for HIV infection has improved since the first immunoassays. Today, diagnosis of HIV infection can be performed with fourth-generation tests that track both the patient's antibodies and HIV antigen. The objective of this study was to evaluate the clinical sensitivity and specificity of the new DiaSorin Liaison XL Murex HIV Ab/Ag assay compared to another fourth-generation assay, the Abbott Architect HIV Ag/Ab Combo kit. This work was performed on a large panel of 900 samples, including negative samples (n = 493) and HIV-positive (n = 407) representatives of HIV-1 group M subtypes and circulating recombinant forms (CRFs), HIV-1 group O, and HIV-2 variants. The results highlight the high specificity (98.9%) and sensitivity (100%) of this new fourth-generation assay, which are consistent with its use for the screening and diagnosis of HIV infections with the current circulating strains.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01089-14