Seroepidemiologic study of human infections with spotted fever group Rickettsiae in North Carolina

Increasing entomologic and epidemiologic evidence suggests that spotted fever group rickettsiae (SFGR) other than Rickettsia rickettsii are responsible for spotted fever rickettsioses in the United States. A retrospective seroepidemiologic study was conducted on stored acute- and convalescent-phase...

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Bibliographic Details
Published in:Journal of clinical microbiology 2014-11, Vol.52 (11), p.3960-3966
Main Authors: Vaughn, Meagan F, Delisle, Josie, Johnson, Joey, Daves, Gaylen, Williams, Carl, Reber, Jodi, Mendell, Nicole L, Bouyer, Donald H, Nicholson, William L, Moncayo, Abelardo C, Meshnick, Steven R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Blotting, Western
Child
Child, Preschool
Chlamydiology and Rickettsiology
Cross Reactions
Female
Humans
Infant
Male
Middle Aged
North Carolina - epidemiology
Retrospective Studies
Rickettsia - immunology
Rickettsia Infections - epidemiology
Rickettsia parkeri
Rickettsia rickettsii
Seroepidemiologic Studies
Young Adult
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Summary:Increasing entomologic and epidemiologic evidence suggests that spotted fever group rickettsiae (SFGR) other than Rickettsia rickettsii are responsible for spotted fever rickettsioses in the United States. A retrospective seroepidemiologic study was conducted on stored acute- and convalescent-phase sera that had been submitted for Rocky Mountain spotted fever testing to the North Carolina State Laboratory of Public Health. We evaluated the serologic reactivity of the paired sera to R. rickettsii, Rickettsia parkeri, and Rickettsia amblyommii antigens. Of the 106 eligible pairs tested, 21 patients seroconverted to one or more antigens. Cross-reactivity to multiple antigens was observed in 10 patients, and seroconversions to single antigens occurred in 11 patients, including 1 against R. rickettsii, 4 against R. parkeri, and 6 against R. amblyommii. Cross-absorption of cross-reactive sera and/or Western blots identified two presumptive cases of infection with R. parkeri, two presumptive cases of infection with R. rickettsii, and one presumptive case of infection with R. amblyommii. These findings suggest that species of SFGR other than R. rickettsii are associated with illness among North Carolina residents and that serologic testing using R. rickettsii antigen may miss cases of spotted fever rickettsioses caused by other species of SFGR.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01733-14