Distribution of Helicobacter pylori in north China

To compare the distribution of virulence-associated genotypes of Helicobacter pylori (H pylori) in two areas of north China with different gastric cancer risk and furthermore probe into the pathogenicity of the bacterium. Gastric biopsies were taken from 355 subjects from Zhuanghe, a high risk area...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-06, Vol.11 (23), p.3523-3527
Main Authors: Gong, Yue-Hua, Wang, Ying, Yuan, Yuan
Format: Article
Language:English
Subjects:
China - epidemiology
Gastric Mucosa - cytology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Genotype
Geography
Helicobacter Pylori
Helicobacter pylori - classification
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Humans
Polymerase Chain Reaction
Stomach Neoplasms - epidemiology
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Summary:To compare the distribution of virulence-associated genotypes of Helicobacter pylori (H pylori) in two areas of north China with different gastric cancer risk and furthermore probe into the pathogenicity of the bacterium. Gastric biopsies were taken from 355 subjects from Zhuanghe, a high risk area of gastric cancer, and 136 subjects from Shenyang, a low risk area of gastric cancer. A total of 149 H pylori strains isolated from these patients were studied by PCR for differences in the genotypes of cagA, vacA, and iceA. In patients with high risk for gastric cancer, higher frequencies of vacA s1 or s1m1b genotypes were found as compared to those from the low risk area. There is significantly different distribution of H pylori genotypes between Zhuanghe and Shenyang areas in north China.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i23.3523