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Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index
AIM:To investigate whether central obesity is associated with nonalcoholic fatty liver disease(NAFLD) formation after adjusting for general obesity.METHODS:The online databases Pub Med,EMBASE,and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurr...
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Published in: | World journal of gastroenterology : WJG 2015-02, Vol.21 (5), p.1650-1662 |
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description | AIM:To investigate whether central obesity is associated with nonalcoholic fatty liver disease(NAFLD) formation after adjusting for general obesity.METHODS:The online databases Pub Med,EMBASE,and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014.Studies that did not adjust for body mass index(BMI) were excluded.In addition,the independent effect of BMI was also assessed with the included studies.The pooled effect sizes and 95% confidence intervals(CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity.Furthermore,subgroup analyses,meta-regression,sensitivity analyses,and publication bias were performed.RESULTS:Twenty eligible studies were identified.The summary odds ratio(OR) values per-unit increase in waist circumference(WC) and BMI for NAFLD formation were 1.07(95%CI:1.03-1.10,I2 = 73.9%,n = 11 studies) and 1.25(95%CI:1.13-1.38,I2 = 88.7%,n = 11 studies),respectively.When the indices were expressed as binary variables(with the non-obesity group as reference),the pooled OR in WC,waist-tohip ratio,and BMI were 2.34(95%CI:1.83-3.00,I2 = 41.8%,n = 7 studies),4.06(95%CI:1.53-10.79,I2 = 65.7%,n = 3 studies),and 2.85(95%CI:1.60-5.08,I2 = 57.8%,n = 5 studies),respectively.Using the same studies as the latter(n = 5),pooled OR in WC was 3.14(95%CI:2.07-4.77),which is greater than that in BMI.CONCLUSION:Central obesity may pose a greater threat to national health than general obesity,although both are independently associated with increased risk of NAFLD. |
doi_str_mv | 10.3748/wjg.v21.i5.1650 |
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Published by Baishideng Publishing Group Inc. All rights reserved. 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a6116b4bbdf9003effd0155415e8c91de100b65475071f21de0f0d203d3a77b53</citedby><cites>FETCH-LOGICAL-c503t-a6116b4bbdf9003effd0155415e8c91de100b65475071f21de0f0d203d3a77b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316109/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316109/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25663786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Qing</creatorcontrib><creatorcontrib>Zhang, Jing-Yao</creatorcontrib><creatorcontrib>Song, Si-Dong</creatorcontrib><creatorcontrib>Qu, Kai</creatorcontrib><creatorcontrib>Xu, Xin-Sen</creatorcontrib><creatorcontrib>Liu, Su-Shun</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><title>Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM:To investigate whether central obesity is associated with nonalcoholic fatty liver disease(NAFLD) formation after adjusting for general obesity.METHODS:The online databases Pub Med,EMBASE,and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014.Studies that did not adjust for body mass index(BMI) were excluded.In addition,the independent effect of BMI was also assessed with the included studies.The pooled effect sizes and 95% confidence intervals(CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity.Furthermore,subgroup analyses,meta-regression,sensitivity analyses,and publication bias were performed.RESULTS:Twenty eligible studies were identified.The summary odds ratio(OR) values per-unit increase in waist circumference(WC) and BMI for NAFLD formation were 1.07(95%CI:1.03-1.10,I2 = 73.9%,n = 11 studies) and 1.25(95%CI:1.13-1.38,I2 = 88.7%,n = 11 studies),respectively.When the indices were expressed as binary variables(with the non-obesity group as reference),the pooled OR in WC,waist-tohip ratio,and BMI were 2.34(95%CI:1.83-3.00,I2 = 41.8%,n = 7 studies),4.06(95%CI:1.53-10.79,I2 = 65.7%,n = 3 studies),and 2.85(95%CI:1.60-5.08,I2 = 57.8%,n = 5 studies),respectively.Using the same studies as the latter(n = 5),pooled OR in WC was 3.14(95%CI:2.07-4.77),which is greater than that in BMI.CONCLUSION:Central obesity may pose a greater threat to national health than general obesity,although both are independently associated with increased risk of NAFLD.</description><subject>Body Mass Index</subject><subject>Central</subject><subject>fatty</subject><subject>Humans</subject><subject>Meta-Analysis</subject><subject>Multivariate Analysis</subject><subject>Non-alcoholic Fatty Liver Disease - diagnosis</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Obesity, Abdominal - diagnosis</subject><subject>Obesity, Abdominal - epidemiology</subject><subject>obesity;General</subject><subject>obesity;Nonalcoholic</subject><subject>Odds Ratio</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Waist Circumference</subject><subject>Waist-Hip Ratio</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVkc1vGyEQxVHVqHGTnHOLOPayzvC1u1wiRVbbVIrUS3KMELuAjbOGBNZO_d8Xx66VIiGkx5sfzDyELglMWcPb67flfLqhZOrFlNQCPqEJpURWtOXwGU0IQFNJRptT9DXnJQBlTNAv6JSKumZNW0_Q08yGMekBx85mP26xDgaHGPTQx0UcfI-dHos8-I1N2PhsdbY4-fyMtRuLpM1ynUcf5tjFhLtotnilc8Y-GPvnHJ04PWR7cTjP0OOP7w-zu-r-989fs9v7qhfAxkrXhNQd7zrjJACzzhkgQnAibNtLYmxppKsFbwQ0xNEigANDgRmmm6YT7Azd7Lkv625lTb_vSb0kv9Jpq6L26v-b4BdqHjeKM1ITkAXw7QBI8XVt86hWPvd2GHSwcZ1VGS4jtBWSFev13tqnmHOy7vgMAbULRZVQVAlFebGrg1Jx9fF3R_-_FIqBHZCLGOavZZhHj4R2t6QA3nIpGG_fNynYv0PimlU</recordid><startdate>20150207</startdate><enddate>20150207</enddate><creator>Pang, Qing</creator><creator>Zhang, Jing-Yao</creator><creator>Song, Si-Dong</creator><creator>Qu, Kai</creator><creator>Xu, Xin-Sen</creator><creator>Liu, Su-Shun</creator><creator>Liu, Chang</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150207</creationdate><title>Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index</title><author>Pang, Qing ; Zhang, Jing-Yao ; Song, Si-Dong ; Qu, Kai ; Xu, Xin-Sen ; Liu, Su-Shun ; Liu, Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a6116b4bbdf9003effd0155415e8c91de100b65475071f21de0f0d203d3a77b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Body Mass Index</topic><topic>Central</topic><topic>fatty</topic><topic>Humans</topic><topic>Meta-Analysis</topic><topic>Multivariate Analysis</topic><topic>Non-alcoholic Fatty Liver Disease - diagnosis</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Obesity, Abdominal - diagnosis</topic><topic>Obesity, Abdominal - epidemiology</topic><topic>obesity;General</topic><topic>obesity;Nonalcoholic</topic><topic>Odds Ratio</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Waist Circumference</topic><topic>Waist-Hip Ratio</topic><toplevel>online_resources</toplevel><creatorcontrib>Pang, Qing</creatorcontrib><creatorcontrib>Zhang, Jing-Yao</creatorcontrib><creatorcontrib>Song, Si-Dong</creatorcontrib><creatorcontrib>Qu, Kai</creatorcontrib><creatorcontrib>Xu, Xin-Sen</creatorcontrib><creatorcontrib>Liu, Su-Shun</creatorcontrib><creatorcontrib>Liu, Chang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Qing</au><au>Zhang, Jing-Yao</au><au>Song, Si-Dong</au><au>Qu, Kai</au><au>Xu, Xin-Sen</au><au>Liu, Su-Shun</au><au>Liu, Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2015-02-07</date><risdate>2015</risdate><volume>21</volume><issue>5</issue><spage>1650</spage><epage>1662</epage><pages>1650-1662</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM:To investigate whether central obesity is associated with nonalcoholic fatty liver disease(NAFLD) formation after adjusting for general obesity.METHODS:The online databases Pub Med,EMBASE,and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014.Studies that did not adjust for body mass index(BMI) were excluded.In addition,the independent effect of BMI was also assessed with the included studies.The pooled effect sizes and 95% confidence intervals(CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity.Furthermore,subgroup analyses,meta-regression,sensitivity analyses,and publication bias were performed.RESULTS:Twenty eligible studies were identified.The summary odds ratio(OR) values per-unit increase in waist circumference(WC) and BMI for NAFLD formation were 1.07(95%CI:1.03-1.10,I2 = 73.9%,n = 11 studies) and 1.25(95%CI:1.13-1.38,I2 = 88.7%,n = 11 studies),respectively.When the indices were expressed as binary variables(with the non-obesity group as reference),the pooled OR in WC,waist-tohip ratio,and BMI were 2.34(95%CI:1.83-3.00,I2 = 41.8%,n = 7 studies),4.06(95%CI:1.53-10.79,I2 = 65.7%,n = 3 studies),and 2.85(95%CI:1.60-5.08,I2 = 57.8%,n = 5 studies),respectively.Using the same studies as the latter(n = 5),pooled OR in WC was 3.14(95%CI:2.07-4.77),which is greater than that in BMI.CONCLUSION:Central obesity may pose a greater threat to national health than general obesity,although both are independently associated with increased risk of NAFLD.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25663786</pmid><doi>10.3748/wjg.v21.i5.1650</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Body Mass Index Central fatty Humans Meta-Analysis Multivariate Analysis Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Obesity, Abdominal - diagnosis Obesity, Abdominal - epidemiology obesity General obesity Nonalcoholic Odds Ratio Prognosis Risk Assessment Risk Factors Waist Circumference Waist-Hip Ratio |
title | Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index |
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