Stereometric parameters change vs. Topographic Change Analysis (TCA) agreement in Heidelberg Retina Tomography III (HRT-3) early detection of clinical significant glaucoma progression

to investigate the sensitivity and specificity of the stereometric parameters change analysis vs. Topographic Change Analysis in early detection of glaucoma progression. 81 patients with POAG were monitored for 4 years (GAT monthly, SAP at every 6 months, optic disc photographs and HRT3 yearly). The...

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Bibliographic Details
Published in:Journal of medicine and life 2014-10, Vol.7 (4), p.555-557
Main Authors: Dascalu, A M, Cherecheanu, A P, Stana, D, Voinea, L, Ciuluvica, R, Savlovschi, C, Serban, D
Format: Article
Language:English
Subjects:
Area Under Curve
Case Presentations
Disease Progression
Early Diagnosis
Glaucoma
Glaucoma - diagnosis
Glaucoma - pathology
Humans
Ophthalmology
Retina - pathology
ROC Curve
Sensitivity and Specificity
Tomography - methods
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Summary:to investigate the sensitivity and specificity of the stereometric parameters change analysis vs. Topographic Change Analysis in early detection of glaucoma progression. 81 patients with POAG were monitored for 4 years (GAT monthly, SAP at every 6 months, optic disc photographs and HRT3 yearly). The exclusion criteria were other optic disc or retinal pathology; topographic standard deviation (TSD>30; inter-test variation of reference height>25 μm. The criterion for structural progression was the following: at least 20 adjacent super-pixels with a clinically significant decrease in height (>5%). 16 patients of the total 81 presented structural progression on TCA. The most useful stereometric parameters for the early detection of glaucoma progression were the following: Rim Area change (sensitivity 100%, specificity 74.2% for a "cut-off " value of -0.05), C/D Area change (sensitivity 85.7%, specificity 71.5% for a "cut off " value of 0.02), C/D linear change (sensitivity 85.7%, specificity 71.5% for a "cut-off " value of 0.02), Rim Volume change (sensitivity 71.4%, specificity 88.8% for a "cut-off " value of -0.04). RNFL Thickness change (
ISSN:1844-122X
1844-3117