Sulindac for stroke treatment： neuroprotective mechanism and therapy

Sulindac, a widely used nonsteroidal anti-inflammatory drug （NSAID） is a prodrug that is reduced by methionine sulfoxide reductase to its active form as an inhibitor of cyclooxygenase 1 and 2. The drug has been shown to elicit tissue protection by processes that may include at least three functions：...

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Bibliographic Details
Published in:Neural regeneration research 2014-12, Vol.9 (23), p.2023-2025
Main Authors: Modi, Jigar Pravinchandra, Prentice, Howard, Wu, Jang-Yen
Format: Article
Language:English
Subjects:
Apoptosis
Arthritis
Brain
Cell culture
Colorectal cancer
Disease
Drug dosages
Drug therapy
Enzymes
FDA approval
Health aspects
Ischemia
Kinases
Metabolites
Nonsteroidal anti-inflammatory drugs
Oxidative stress
Proteins
Stroke
Sulindac
中风
保护机制
功能组织
抗氧化剂
治疗
环氧合酶
甲硫氨酸
神经保护
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Summary:Sulindac, a widely used nonsteroidal anti-inflammatory drug （NSAID） is a prodrug that is reduced by methionine sulfoxide reductase to its active form as an inhibitor of cyclooxygenase 1 and 2. The drug has been shown to elicit tissue protection by processes that may include at least three functions： antioxidant, preconditioning and anti-inflammatory. Sulindac demonstrates neuroprotection that involves inhibition of mitochondrial calcium overload or a decrease in protein oxidation.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.147919