Procalcitonin as a diagnostic marker of ventilator-associated pneumonia in cardiac surgery patients

The aim of the present study was to assess whether procalcitonin (PCT) can be used as a diagnostic marker for ventilator-associated pneumonia (VAP) in cardiac surgery patients. Between January 2012 and June 2013, a total of 92 patients were recruited and divided into non-VAP (59 patients) and VAP (3...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-03, Vol.9 (3), p.1051-1057
Main Authors: JIAO, JIA, WANG, MIN, ZHANG, JIANFENG, SHEN, KANGJUN, LIAO, XIAOBO, ZHOU, XINMIN
Format: Article
Language:English
Subjects:
Antibiotics
Bacterial infections
Biological markers
Cardiac patients
cardiac surgery
Cytokines
Development and progression
diagnostic marker
Heart
Heart surgery
Hospitals
Intensive care
Medical diagnosis
Medical research
Medicine, Experimental
Mortality
Nosocomial infections
Patients
Physiological aspects
Pneumonia
procalcitonin
Proteins
Standard deviation
Statistical analysis
Studies
Surgery
Ventilator-associated pneumonia
Ventilators
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Summary:The aim of the present study was to assess whether procalcitonin (PCT) can be used as a diagnostic marker for ventilator-associated pneumonia (VAP) in cardiac surgery patients. Between January 2012 and June 2013, a total of 92 patients were recruited and divided into non-VAP (59 patients) and VAP (33 patients) groups. The preoperative and postoperative characteristics of the patients were recorded. Serum levels of PCT, interleukin (IL)-6 and C-reactive protein (CRP) were measured using an electrochemiluminescence immunoassay. Subsequently, receiver operating characteristic curves of the PCT, IL-6 and CRP levels were constructed. In addition, associations between the sequential organ failure assessment (SOFA) scores and the serum levels of PCT, IL-6 and CRP in the VAP patients were analyzed. No statistically significant difference was observed between the non-VAP and VAP patients in the occurrence of postoperative complications. However, the SOFA scores (days 1 and 7), the duration of stay in the intensive care unit and the mechanical ventilation time were all significantly higher in the VAP group when compared with the non-VAP group (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2015.2175