Long non‐coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR–STAT3/microRNA143 pathway

Cancer cells preferentially metabolize glucose through aerobic glycolysis, a phenomenon known as the Warburg effect. Emerging evidence has shown that long non‐coding RNAs (lncRNAs) act as key regulators of multiple cancers. However, it remains largely unexplored whether and how lncRNA regulates gluc...

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Bibliographic Details
Published in:Cancer science 2014-08, Vol.105 (8), p.951-955
Main Authors: Li, Zhengkun, Li, Xu, Wu, Shouzhen, Xue, Mei, Chen, Wei
Format: Article
Language:English
Subjects:
Aerobic glycolysis
Apoptosis
Bladder cancer
Blotting, Western
Cancer
cancer metabolism
Cell culture
Cell Line, Tumor
Gene expression
Glucose - metabolism
Glycolysis
Glycolysis - physiology
Hexokinase
Hexokinase - biosynthesis
Humans
lncRNA
Metabolism
MicroRNAs
MicroRNAs - metabolism
miRNA
Original
Real-Time Polymerase Chain Reaction
RNA, Long Noncoding - metabolism
Signal Transduction - physiology
Software
Stat3 protein
STAT3 Transcription Factor - metabolism
TOR protein
TOR Serine-Threonine Kinases - metabolism
UCA1
Up-Regulation
Urinary Bladder Neoplasms - metabolism
Warburg effect
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Summary:Cancer cells preferentially metabolize glucose through aerobic glycolysis, a phenomenon known as the Warburg effect. Emerging evidence has shown that long non‐coding RNAs (lncRNAs) act as key regulators of multiple cancers. However, it remains largely unexplored whether and how lncRNA regulates glucose metabolism in cancer cells. In this study, we show that lncRNA UCA1 promotes glycolysis in bladder cancer cells, and that UCA1‐induced hexokinase 2 (HK2) functions as an important mediator in this process. We further show that UCA1 activates mTOR to regulate HK2 through both activation of STAT3 and repression of microRNA143. Taken together, these findings provide the first evidence that UCA1 plays a positive role in cancer cell glucose metabolism through the cascade of mTOR–STAT3/microRNA143–HK2, and reveal a novel link between lncRNA and the altered glucose metabolism in cancer cells. UCA1 plays a positive role in cancer cell glucose metabolism. UCA1 exerts its role in glycolysis through the cascade of mTOR‐STAT3/miR143‐HK2.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12461