The clinical significance of CDK1 expression in oral squamous cell carcinoma

To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the...

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Bibliographic Details
Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2015-01, Vol.20 (1), p.e7-e12
Main Authors: Chen, Xin, Zhang, Feng-He, Chen, Qiao-Er, Wang, Yuan-Yin, Wang, Yin-Long, He, Jia-Cai, Zhou, Jian
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - enzymology
CDC2 Protein Kinase - analysis
CDC2 Protein Kinase - biosynthesis
Dentistry
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mouth Neoplasms - chemistry
Mouth Neoplasms - enzymology
Survival Rate
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Summary:To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In addition, correlation of CDK1 expression and prognostic and the 5-year accumulative survival rate of OSCC were investigated. The CDK1 protein was expressed in 52 cases of 77 tumor tissues (67.5%), compared with 21 cases of 60 controlled (35.0%). The expression of CDK1 was significantly correlated with the histological grade of OSCC (P
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.19841