Maternal immune activation leads to activated inflammatory macrophages in offspring

Highlight • Bone marrow derived macrophages from offspring of dams exposed to maternal immune activation during gestation show increased IL-12p40 production and M1 skewing.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2014-05, Vol.38, p.220-226
Main Authors: Onore, Charity E, Schwartzer, Jared J, Careaga, Milo, Berman, Robert F, Ashwood, Paul
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cytokines - metabolism
Female
Inflammation - immunology
Macrophages - immunology
Mice
Mice, Inbred C57BL
Pregnancy
Prenatal Exposure Delayed Effects - immunology
Psychiatry
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Description
Summary:Highlight • Bone marrow derived macrophages from offspring of dams exposed to maternal immune activation during gestation show increased IL-12p40 production and M1 skewing.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.02.007