The Effect of Acetoxycycloheximide on Rate of Accumulation of Cerebral Catecholamines from Circulating Tyrosine as Related to its Effect on Memory

The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severely decreased for a period of 12 hr after injection. Total catecholamine l...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1975-02, Vol.72 (2), p.479-482
Main Authors: Goodman, Richard H., Flexner, Josefa B., Flexner, Louis B.
Format: Article
Language:English
Subjects:
Adrenergics
Amnesia
Anesthetics
Animals
Brain - drug effects
Brain - metabolism
Catecholamines
Catecholamines - metabolism
Cerebral hemispheres
Control groups
Cycloheximide - analogs & derivatives
Cycloheximide - pharmacology
Decapitation
Dopamine - metabolism
Dosage
Female
Kinetics
Memory - drug effects
Mice
Norepinephrine - metabolism
Protein synthesis
Radioactive decay
Tyrosine - metabolism
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Summary:The rate of accumulation of newly synthesized catecholamines and endogenous catecholamine levels in mice were determined after an amnestic intracranial dose of acetoxycycloheximide. Rates of accumulation were found to be severely decreased for a period of 12 hr after injection. Total catecholamine levels were increased from 1 to 4 hr, then decreased 17 hr following injection. These results are discussed in terms of previous behavioral observations. It is pointed out that they weaken the assumption that acetoxycycloheximide's amnestic effects are solely due to inhibition of protein synthesis.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.72.2.479