Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes

There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood. The objective of the present investigation was to explore the clinical and laboratory features of seven patie...

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Bibliographic Details
Published in:Cancer cell international 2014-12, Vol.14 (1), p.111-111, Article 111
Main Authors: He, GanLin, Wang, ChunYan, Li, QingEn, Tan, Huo, Chen, FuXiong, Huang, ZhenQian, Yu, BaoDan, Zheng, LiXia, Zheng, RunHui, Liu, Dan
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Bone marrow
Classification
Fever
Hematology
Hyperactivity
Immunology
Laboratories
Leukemia
Medical prognosis
Morphology
Patients
Pediatrics
Primary Research
Respiratory diseases
Stem cells
Transplants & implants
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Summary:There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood. The objective of the present investigation was to explore the clinical and laboratory features of seven patients with AML-M2/M3. We retrospectively assessed cell morphology, cytochemistry, immunophenotype, cytogenetics, and clinical features of seven patients with this rare subtype of AML. All seven cases had thrombocytopenia, coagulation abnormalities, >20% myeloblasts and abnormal promyelocytes. The PML/RARα fusion gene was present in six patients and two patients presented a mixed PML/RARα and AML1/ETO genotype. Five cases achieved CR and two cases did not achieve remission and one case transform into AML-M2 after CR1. The clinical and laboratory features of seven patients with AML-M2/M3 are demonstrated in the present study, providing information on the FAB sub-classification.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-014-0111-y