Biochemical Storage Lesions Occurring in Nonirradiated and Irradiated Red Blood Cells: A Brief Review

Red blood cells undergo a series of biochemical fluctuations during 35–42-day storage period at 1°C to 6°C. The sodium/potassium pump is immobilised causing a decrease in intracellular potassium with an increase in cytoplasmic sodium levels, glucose levels decline, and acidosis occurs as a result of...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Oguntibeju, Oluwafemi O., Bird, A. R., Bellairs, G., Adams, F.
Format: Article
Language:English
Subjects:
Animals
Anticoagulants
Biomedical research
Blood & organ donations
Blood Preservation - methods
Blood products
Blood transfusions
Cell interaction
Cells, Cultured
Dose-Response Relationship, Radiation
Erythrocyte Transfusion
Erythrocytes
Erythrocytes - cytology
Erythrocytes - metabolism
Erythrocytes - radiation effects
Gamma rays
Glucose
Health aspects
Humans
Intensive care
Irradiation
Metabolism
Morbidity
Mortality
Observations
Patients
Phosphates
Radiation Dosage
Review
Sodium
Specimen Handling
Studies
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Summary:Red blood cells undergo a series of biochemical fluctuations during 35–42-day storage period at 1°C to 6°C. The sodium/potassium pump is immobilised causing a decrease in intracellular potassium with an increase in cytoplasmic sodium levels, glucose levels decline, and acidosis occurs as a result of low pH levels. The frailty of stored erythrocytes triggers the formation of haemoglobin-containing microparticles and the release of cell-free haemoglobin which may add to transfusion difficulties. Lipid peroxidation, oxidative stress to band 3 structures, and other morphological and structural molecular changes also occur leading to spheroechinocytes and osmotic fragility. These changes that transpire in the red cells during the storage period are referred to as “storage lesions.” It is well documented that gamma irradiation exacerbates storage lesions and the reports of increased potassium levels leading to adverse reactions observed in neonates and infants have been of particular concern. There are, however, remarkably few systematic studies comparing the in vitro storage lesions of irradiated and nonirradiated red cell concentrates and it has been suggested that the impact of storage lesions on leucocyte reduced red blood cell concentrate (RBCC) is incomplete. The review examines storage lesions in red blood cells and their adverse effects in reference to blood transfusion.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/968302