Unlike Bone, Cartilage Regeneration Remains Elusive

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus,...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2012-11, Vol.338 (6109), p.917-921
Main Authors: Huey, Daniel J., Hu, Jerry C., Athanasiou, Kyriacos A.
Format: Article
Language:English
Subjects:
Articular
Bioengineering
Biomechanical Phenomena
Biomechanics
Bone and Bones - physiology
Bone Regeneration
Bones
Cartilage
Cartilage, Articular - physiology
Chondrocytes
Collagens
Design engineering
Healing
Humans
Materials selection
Mechanical properties
Mesenchymal Stromal Cells - physiology
Osteoblasts - physiology
Osteoclasts - physiology
Regeneration
REVIEW
Scaffolds
Stem cells
Tissue engineering
Tissue Engineering - methods
Tissue repair
Tissue Scaffolds
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Summary:Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. We also discuss technologies that can address the hurdles of engineering a tissue possessing mechanical properties that are unmatched in human-made materials and functioning in environments unfavorable to neotissue growth.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1222454