Surgery in the era of the 'omics revolution

Background Surgery is entering a new phase with the revolution in genomic technology. Cheap, mass access to next‐generation sequencing is now allowing the analysis of entire human genomes at the DNA and RNA level. These data sets are being used increasingly to identify the molecular differences that...

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Bibliographic Details
Published in:British journal of surgery 2015-01, Vol.102 (2), p.e29-e40
Main Authors: Beggs, A. D., Dilworth, M. P.
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Breast Neoplasms - genetics
Breast Neoplasms - surgery
Early Detection of Cancer - methods
Early Detection of Cancer - trends
Female
Forecasting
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - surgery
Genetic Predisposition to Disease - genetics
Genetic Testing - methods
Genetic Testing - trends
Genome-Wide Association Study - methods
Genome-Wide Association Study - trends
Genomes
Genomics - methods
Genomics - trends
Humans
Inventions - trends
Metabolomics - trends
Molecular Targeted Therapy - methods
Molecular Targeted Therapy - trends
Mutation - genetics
Prognosis
Review
Reviews
Therapies, Investigational - methods
Therapies, Investigational - trends
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Summary:Background Surgery is entering a new phase with the revolution in genomic technology. Cheap, mass access to next‐generation sequencing is now allowing the analysis of entire human genomes at the DNA and RNA level. These data sets are being used increasingly to identify the molecular differences that underlie common surgical diseases, and enable them to be stratified for patient benefit. Methods This article reviews the recent developments in the molecular biology of colorectal, oesophagogastric and breast cancer. Results The review specifically covers developments in genetic predisposition, next‐generation sequencing studies, biomarkers for stratification, prognosis and treatment, and other 'omics technologies such as metabolomics and proteomics. Conclusion There are unique opportunities over the next decade to change the management of surgical disease radically, using these technologies. The directions that this may take are highlighted, including future advances such as the 100 000 Genomes Project. May individualize cancer treatment
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.9722