Invasive Haemophilus influenzae in the United States, 1999–2008: Epidemiology and outcomes

Summary Objectives Introduction of the Haemophilus influenzae type b (Hib) conjugate vaccine has resulted in a dramatic reduction of Hib disease in the U.S. and an increase in the relative importance of infections caused by nontypeable strains. The current project describes the characteristics and c...

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Bibliographic Details
Published in:The Journal of infection 2012-12, Vol.65 (6), p.496-504
Main Authors: Livorsi, Daniel J, MacNeil, Jessica R, Cohn, Amanda C, Bareta, Joseph, Zansky, Shelly, Petit, Susan, Gershman, Ken, Harrison, Lee H, Lynfield, Ruth, Reingold, Arthur, Schaffner, William, Thomas, Ann, Farley, Monica M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Community-Acquired Infections - therapy
Cross Infection - epidemiology
Cross Infection - microbiology
Cross Infection - therapy
General aspects
Haemophilus Infections - epidemiology
Haemophilus Infections - microbiology
Haemophilus Infections - therapy
Haemophilus influenzae
Haemophilus influenzae - classification
Haemophilus influenzae - isolation & purification
Haemophilus influenzae - pathogenicity
Hospital Mortality
Humans
Infant
Infectious Disease
Logistic Models
Medical sciences
Middle Aged
Mortality
Multivariable analysis
Population Surveillance
Risk Factors
Serotyping
Treatment Outcome
United States
United States - epidemiology
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Summary:Summary Objectives Introduction of the Haemophilus influenzae type b (Hib) conjugate vaccine has resulted in a dramatic reduction of Hib disease in the U.S. and an increase in the relative importance of infections caused by nontypeable strains. The current project describes the characteristics and clinical outcomes of pediatric and adult patients with invasive H. influenzae (HI) and, through multivariable analysis, identifies risk factors for in-hospital mortality. Methods HI cases were identified during 1999–2008 through active surveillance as part of Active Bacterial Core surveillance (ABCs). Multivariable analysis was performed with logistic regression to identify factors predictive of in-hospital death. Results 4839 cases of HI were identified from 1999–2008. Children accounted for 17.1% of cases and adults 82.9%. Underlying conditions were present in 20.7% of children and 74.8% of adults. In-hospital mortality was highest in cases ≥65 years (21.9%) and
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2012.08.005