Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism

CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding s...

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Bibliographic Details
Published in:Annual review of nutrition 2014-01, Vol.34 (1), p.281-303
Main Authors: Pepino, Marta Yanina, Kuda, Ondrej, Samovski, Dmitri, Abumrad, Nada A
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Biological Transport
CD36 Antigens - blood
CD36 Antigens - chemistry
CD36 Antigens - metabolism
Chylomicrons - blood
Chylomicrons - metabolism
Dietary Fats - metabolism
Fatty Acids, Nonesterified - blood
Fatty Acids, Nonesterified - metabolism
Humans
Lipoproteins, VLDL - blood
Lipoproteins, VLDL - metabolism
Models, Biological
Protein Conformation
Signal Transduction
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Summary:CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids. Thus abnormalities of fat metabolism and the associated pathology might involve dysfunction of CD36-mediated signal transduction in addition to the changes in FA uptake.
ISSN:0199-9885
1545-4312
DOI:10.1146/annurev-nutr-071812-161220