The Potential Role of Polymethyl Methacrylate as a New Packaging Material for the Implantable Medical Device in the Bladder

• Published in: BioMed research international 2015-01, Vol.2015 (2015), p.1-8
• Main Authors: Kim, Sae Woong, Lee, Ji Youl, Hong, Sung Hoo, Bae, Woong Jin, Kim, Kang Sup, Choi, Bumkyoo, Kim, Su Jin, Hwang, Tae-Kon
• Format: Article
• Language: English
• Subjects: Animals; Biocompatibility; Biocompatible Materials - chemistry; Biocompatible Materials - therapeutic use; Bladder; Cytokines; Cytokines - biosynthesis; Equipment and Supplies - microbiology; Gene Expression - drug effects; Humans; Implantation; Implants, Artificial; Intramolecular Oxidoreductases - biosynthesis; Macrophage Migration-Inhibitory Factors - biosynthesis; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Medical devices; Medical equipment; Packaging; Polymethyl Methacrylate - adverse effects; Polymethyl Methacrylate - chemistry; Polymethyl Methacrylate - therapeutic use; Polymethyl methacrylates; Polymethylmethacrylate; Product Packaging; Prostheses and Implants; Prosthesis; Rats; Rodents; Silicone resins; Studies; Urinary Bladder - microbiology; Urinary Bladder - surgery
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/852456

Polydimethylsiloxane (PDMS) is used in implantable medical devices; however, PDMS is not a completely biocompatible material for electronic medical devices in the bladder. To identify novel biocompatible materials for intravesical implanted medical devices, we evaluated the biocompatibility of polymethyl methacrylate (PMMA) by analyzing changes in the levels of macrophages, macrophage migratory inhibitory factor (MIF), and inflammatory cytokines in the bladder. A ball-shaped metal coated with PMMA or PDMS was implanted into the bladders of rats, and after intravesical implantation, the inflammatory changes induced by the foreign body reaction were evaluated. In the early period after implantation, increased macrophage activity and MIF in the urothelium of the bladder were observed. However, significantly decreased macrophage activity and MIF in the bladder were observed after implantation with PMMA- or PDMS-coated metal in the later period. In addition, significantly decreased inflammatory cytokines such as IL-1β, IL-6, and TNF-α were observed with time. Based on these results, we suggest that MIF plays a role in the foreign body reaction and in the biocompatible packaging with PMMA for the implanted medical devices in the bladder.