Severity of rhinovirus infection in hospitalized adults is unrelated to genotype

To determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults. Seventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the...

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Bibliographic Details
Published in:American Journal of Clinical Pathology 2014-08, Vol.142 (2), p.165-172
Main Authors: McCulloch, Denise J, Sears, Marti H, Jacob, Jesse T, Lyon, G Marshall, Burd, Eileen M, Caliendo, Angela M, Hill, Charles E, Nix, W Allan, Oberste, M Steven, Kraft, Colleen S
Format: Article
Language:English
Subjects:
Adult
Aged
Asthma - diagnosis
Asthma - virology
Female
Genetic Testing - methods
Genotype
Hospitalization
Humans
Male
Middle Aged
Original
Picornaviridae Infections - virology
Respiratory Tract Infections - diagnosis
Respiratory Tract Infections - virology
Reverse Transcriptase Polymerase Chain Reaction - methods
Rhinovirus - genetics
RNA, Viral - analysis
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Summary:To determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults. Seventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the VP4 gene and 5' terminus of the VP2 gene. The clinical features and severity of illness associated with the different RV species were compared. Phylogenetic analysis identified three distinct clusters as RV-A (54%), B (11%), or C (35%) species. In an unadjusted model, patients with RV-B infection were significantly more likely to have the composite outcome variable of death or intensive care unit admission (P=.03), but this effect diminished when controlling for patient sex. A logistic model of the relationship between RV species and adverse outcomes produced nonsignificant odds ratios when controlling for patient sex. Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPHIKRJC67AAZJ