Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

• Published in: BioMed research international 2015-01, Vol.2015 (2015), p.1-4
• Main Authors: Guducuoglu, Huseyin, Aydin, Mehmet Nuri, Delen, Veysel, Milanlıoğlu, Aysel, Alpayci, Mahmut, Bayram, Yasemin
• Format: Article
• Language: English
• Subjects: Adult; Age; Antibodies; Antibodies, Anti-Idiotypic - blood; Antibodies, Anti-Idiotypic - immunology; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Blood-brain barrier; Brain; Central Nervous System - immunology; Central Nervous System - pathology; Citrulline - metabolism; Correlation analysis; Disease; Drug therapy; Early Diagnosis; Enzymes; Female; Gender; Health aspects; Humans; Male; Medicine; Middle Aged; Multiple sclerosis; Multiple Sclerosis - blood; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Myelin Basic Protein - metabolism; Pathogenesis; Peptides - blood; Peptides - immunology; Physiological aspects; Proteins; Rheumatology; Statistical analysis; Studies; Variance analysis; Viral antibodies
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/817427

Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls ( P < 0.001 ) . Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores ( r = - 0.250 ) . In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.