Inhibition of Murine Leukemia Virus Replication by Poly(vinyluracil) and Poly(vinyladenine)

Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1973-04, Vol.70 (4), p.1204-1208
Main Authors: Pitha, Paula M., Teich, Natalie M., Lowy, Douglas R., Pitha, Josef
Format: Article
Language:English
Subjects:
Adenine Nucleotides - pharmacology
Animals
Biological Sciences: Microbiology
Cell Division - drug effects
Cell growth
Cell Line
DNA
DNA Nucleotidyltransferases - antagonists & inhibitors
Embryo, Mammalian
Humans
Infections
Kidney
Kidney cells
L cells
Lung
Mice
Moloney murine leukemia virus - drug effects
Moloney murine leukemia virus - enzymology
Polymers
Polynucleotides
Polynucleotides - pharmacology
Reverse Transcriptase Inhibitors
Sindbis Virus - drug effects
Swiss 3T3 cells
Uracil Nucleotides - pharmacology
Vesicular stomatitis Indiana virus - drug effects
Vinyl Compounds - pharmacology
Vinyl polymers
Virus Replication - drug effects
Viruses
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Description
Summary:Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.70.4.1204