Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma

Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University f...

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Published in:Journal of Oncology 2015-01, Vol.2015 (2015), p.336-343
Main Authors: Okabe, Naoyuki, Matsumura, Yuki, Yonechi, Athushi, Hoshino, Mika, Higuchi, Mitsunori, Shio, Yutaka, Suzuki, Hiroyuki, Gotoh, Mitsukazu, Muto, Satoshi, Fukuhara, Mitsuro, Yamaura, Takumi, Watanabe, Yuzuru, Inoue, Takuya, Owada, Yuki, Kimura, Yuka, Osugi, Jun, Hasegawa, Takeo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Angiogenesis
Apoptosis
Cell cycle
Cell growth
Gene expression
Genetic aspects
Histology
Hypoxia
Lung cancer
Lung cancer, Non-small cell
Lymphatic system
Medical prognosis
Metabolism
Metastasis
MicroRNA
MicroRNAs
Patients
Physiological aspects
Surgery
Survival analysis
Tumors
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Summary:Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.
ISSN:1687-8450
1687-8450
DOI:10.1155/2015/316745