Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma

Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University f...

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Published in:Journal of Oncology 2015-01, Vol.2015 (2015), p.336-343
Main Authors: Okabe, Naoyuki, Matsumura, Yuki, Yonechi, Athushi, Hoshino, Mika, Higuchi, Mitsunori, Shio, Yutaka, Suzuki, Hiroyuki, Gotoh, Mitsukazu, Muto, Satoshi, Fukuhara, Mitsuro, Yamaura, Takumi, Watanabe, Yuzuru, Inoue, Takuya, Owada, Yuki, Kimura, Yuka, Osugi, Jun, Hasegawa, Takeo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Angiogenesis
Apoptosis
Cell cycle
Cell growth
Gene expression
Genetic aspects
Histology
Hypoxia
Lung cancer
Lung cancer, Non-small cell
Lymphatic system
Medical prognosis
Metabolism
Metastasis
MicroRNA
MicroRNAs
Patients
Physiological aspects
Surgery
Survival analysis
Tumors
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cited_by cdi_FETCH-LOGICAL-a527t-945be269b58d6949163a052c48265044ab863b662d0bde3a2d037419837379303
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container_title Journal of Oncology
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creator Okabe, Naoyuki
Matsumura, Yuki
Yonechi, Athushi
Hoshino, Mika
Higuchi, Mitsunori
Shio, Yutaka
Suzuki, Hiroyuki
Gotoh, Mitsukazu
Muto, Satoshi
Fukuhara, Mitsuro
Yamaura, Takumi
Watanabe, Yuzuru
Inoue, Takuya
Owada, Yuki
Kimura, Yuka
Osugi, Jun
Hasegawa, Takeo
description Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.
doi_str_mv 10.1155/2015/316745
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The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.</description><identifier>ISSN: 1687-8450</identifier><identifier>EISSN: 1687-8450</identifier><identifier>DOI: 10.1155/2015/316745</identifier><identifier>PMID: 25733977</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><subject>Adenocarcinoma ; Angiogenesis ; Apoptosis ; Cell cycle ; Cell growth ; Gene expression ; Genetic aspects ; Histology ; Hypoxia ; Lung cancer ; Lung cancer, Non-small cell ; Lymphatic system ; Medical prognosis ; Metabolism ; Metastasis ; MicroRNA ; MicroRNAs ; Patients ; Physiological aspects ; Surgery ; Survival analysis ; Tumors</subject><ispartof>Journal of Oncology, 2015-01, Vol.2015 (2015), p.336-343</ispartof><rights>Copyright © 2015 Jun Osugi et al.</rights><rights>COPYRIGHT 2015 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2015 Jun Osugi et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2015 Jun Osugi et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a527t-945be269b58d6949163a052c48265044ab863b662d0bde3a2d037419837379303</citedby><cites>FETCH-LOGICAL-a527t-945be269b58d6949163a052c48265044ab863b662d0bde3a2d037419837379303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2407634863/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2407634863?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25733977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mulshine, James L.</contributor><contributor>James L Mulshine</contributor><creatorcontrib>Okabe, Naoyuki</creatorcontrib><creatorcontrib>Matsumura, Yuki</creatorcontrib><creatorcontrib>Yonechi, Athushi</creatorcontrib><creatorcontrib>Hoshino, Mika</creatorcontrib><creatorcontrib>Higuchi, Mitsunori</creatorcontrib><creatorcontrib>Shio, Yutaka</creatorcontrib><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Gotoh, Mitsukazu</creatorcontrib><creatorcontrib>Muto, Satoshi</creatorcontrib><creatorcontrib>Fukuhara, Mitsuro</creatorcontrib><creatorcontrib>Yamaura, Takumi</creatorcontrib><creatorcontrib>Watanabe, Yuzuru</creatorcontrib><creatorcontrib>Inoue, Takuya</creatorcontrib><creatorcontrib>Owada, Yuki</creatorcontrib><creatorcontrib>Kimura, Yuka</creatorcontrib><creatorcontrib>Osugi, Jun</creatorcontrib><creatorcontrib>Hasegawa, Takeo</creatorcontrib><title>Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma</title><title>Journal of Oncology</title><addtitle>J Oncol</addtitle><description>Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. 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subjects Adenocarcinoma
Angiogenesis
Apoptosis
Cell cycle
Cell growth
Gene expression
Genetic aspects
Histology
Hypoxia
Lung cancer
Lung cancer, Non-small cell
Lymphatic system
Medical prognosis
Metabolism
Metastasis
MicroRNA
MicroRNAs
Patients
Physiological aspects
Surgery
Survival analysis
Tumors
title Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma
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