The role of the insulin-like growth factor-1 system in breast cancer

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a g...

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Bibliographic Details
Published in:Molecular cancer 2015-02, Vol.14 (1), p.43-43
Main Authors: Christopoulos, Panagiotis F, Msaouel, Pavlos, Koutsilieris, Michael
Format: Article
Language:English
Subjects:
Animals
Binding proteins
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinogenesis - genetics
Carcinogenesis - pathology
Development and progression
Estrogen
Female
Humans
Insulin-Like Growth Factor I - genetics
Metastasis
Mitogens
Physiological aspects
Protein binding
Review
Signal Transduction - genetics
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Summary:IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-015-0291-7