Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not d...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-02, Vol.59 (2), p.1356-1359
Main Authors: Kayama, Shizuo, Shigemoto, Norifumi, Kuwahara, Ryuichi, Oshima, Kenshiro, Hirakawa, Hideki, Hisatsune, Junzo, Jové, Thomas, Nishio, Hisaaki, Yamasaki, Katsutoshi, Wada, Yasunao, Ueshimo, Takeshi, Miura, Tetsuya, Sueda, Taijiro, Onodera, Makoto, Yokozaki, Michiya, Hattori, Masahira, Ohge, Hiroki, Sugai, Motoyuki
Format: Article
Language:English
Subjects:
beta-Lactamases
beta-Lactamases - metabolism
Enterobacteriaceae
Enterobacteriaceae - drug effects
Enterobacteriaceae - enzymology
Epidemiology and Surveillance
Imipenem - pharmacology
Japan
Klebsiella pneumoniae
Microbial Sensitivity Tests
Molecular Sequence Data
Plasmids - genetics
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Summary:We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.04759-14