Hepcidin and risk of anemia in CKD: a cross-sectional and longitudinal analysis in the CKiD cohort

Background Hepcidin, a key iron regulatory protein, is elevated in patients with chronic kidney disease (CKD). Its role in the development and progression of the anemia of CKD in children remains poorly defined. Methods Cross-sectional and longitudinal study in children aged 1–16 years with stage 2–...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-04, Vol.30 (4), p.635-643
Main Authors: Atkinson, Meredith A., Kim, Ji Young, Roy, Cindy N., Warady, Bradley A., White, Colin T., Furth, Susan L.
Format: Article
Language:English
Subjects:
Adolescent
Anemia
Anemia - blood
Child
Child, Preschool
Chronic kidney failure
Cohort analysis
Complications and side effects
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Glomerular Filtration Rate
Hemoglobin
Hemoglobins - metabolism
Hepcidins - blood
Humans
Infant
Iron
Kidney diseases
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Metalloproteins
Nephrology
Original Article
Pediatrics
Physiological aspects
Prognosis
Proteins
Renal Insufficiency, Chronic - blood
Risk Factors
Urology
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Summary:Background Hepcidin, a key iron regulatory protein, is elevated in patients with chronic kidney disease (CKD). Its role in the development and progression of the anemia of CKD in children remains poorly defined. Methods Cross-sectional and longitudinal study in children aged 1–16 years with stage 2–4 CKD in the Chronic Kidney Disease in Children (CKiD) cohort ( n  = 133) with hepcidin measured at baseline and hemoglobin (HGB) measured annually at follow-up. Anemia was defined as HGB
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-014-2991-4