Neuroepigenomics: resources, obstacles, and opportunities

Long-lived postmitotic cells, such as most human neurons, must respond effectively to ongoing changes in neuronal stimulation or microenvironmental cues through transcriptional and epigenomic regulation of gene expression. The role of epigenomic regulation in neuronal function is of fundamental inte...

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Bibliographic Details
Published in:Neuroepigenetics 2015-01, Vol.1, p.2-13
Main Authors: Satterlee, John S., Beckel-Mitchener, Andrea, Little, A. Roger, Procaccini, Dena, Rutter, Joni L., Lossie, Amy C.
Format: Article
Language:English
Subjects:
Epigenome
Methylation
Obstacles
Opportunities
Resources
Technology
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Summary:Long-lived postmitotic cells, such as most human neurons, must respond effectively to ongoing changes in neuronal stimulation or microenvironmental cues through transcriptional and epigenomic regulation of gene expression. The role of epigenomic regulation in neuronal function is of fundamental interest to the neuroscience community, as these types of studies have transformed our understanding of gene regulation in postmitotic cells. This perspective article highlights many of the resources available to researchers interested in neuroepigenomic investigations and discusses some of the current obstacles and opportunities in neuroepigenomics.
ISSN:2214-7845
2214-7845
DOI:10.1016/j.nepig.2014.10.001