Ultrasensitive Biosensors Using Enhanced Fano Resonances in Capped Gold Nanoslit Arrays

• Published in: Scientific reports 2015-02, Vol.5 (1), p.8547-8547, Article 8547
• Main Authors: Lee, Kuang-Li, Huang, Jhih-Bin, Chang, Jhih-Wei, Wu, Shu-Han, Wei, Pei-Kuen
• Format: Article
• Language: English
• Subjects: 142/126; 631/61/350/2251; 631/61/350/59; 639/624/400/1021; 639/925/350/2093; 82/103; 9/10; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensors; Gold; Gold - chemistry; Humanities and Social Sciences; Microarray Analysis; Microscopy, Atomic Force; multidisciplinary; Nanostructures - chemistry; Polymers - chemistry; Science; Sensors; Silicon - chemistry; Surface Plasmon Resonance
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep08547

Nanostructure-based sensors are capable of sensitive and label-free detection for biomedical applications. However, plasmonic sensors capable of highly sensitive detection with high-throughput and low-cost fabrication techniques are desirable. We show that capped gold nanoslit arrays made by thermal-embossing nanoimprint method on a polymer film can produce extremely sharp asymmetric resonances for a transverse magnetic-polarized wave. An ultrasmall linewidth is formed due to the enhanced Fano coupling between the cavity resonance mode in nanoslits and surface plasmon resonance mode on periodic metallic surface. With an optimal slit length and width, the full width at half-maximum bandwidth of the Fano mode is only 3.68 nm. The wavelength sensitivity is 926 nm/RIU for 60-nm-width and 1,000-nm-period nanoslits. The figure of merit is up to 252. The obtained value is higher than the theoretically estimated upper limits of the prism-coupling SPR sensors and the previously reported record high figure-of-merit in array sensors. In addition, the structure has an ultrahigh intensity sensitivity up to 48,117%/RIU.