The avascular zone and neuronal remodeling of the fovea in Parkinson disease

Inner foveal thinning and intracellular alpha‐synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha‐synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non‐DA neurons....

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Published in:Annals of clinical and translational neurology 2015-02, Vol.2 (2), p.196-201
Main Authors: Miri, Shahnaz, Shrier, Eric M., Glazman, Sofya, Ding, Yin, Selesnick, Ivan, Kozlowski, Piotr B., Bodis‐Wollner, Ivan
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biomarkers
Brief Communications
Diabetic retinopathy
Medical imaging
Parkinson's disease
Pathology
Retina
Software
Statistical analysis
Tomography
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cited_by cdi_FETCH-LOGICAL-c4386-a26bc6408846a75d664de85a8dd46f653a0ae94c68ebc6dac9149275c294be0f3
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container_title Annals of clinical and translational neurology
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creator Miri, Shahnaz
Shrier, Eric M.
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description Inner foveal thinning and intracellular alpha‐synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha‐synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non‐DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 healthy controls using retinal fluorescein angiography and optical coherence tomography. The size of the foveal avascular zone inversely correlates with foveal thinning. Foveal thinning highly correlates with motor impairment and also disease duration. Quantifying capillary and neuronal remodeling could serve as biological markers.
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database; PubMed Central
subjects Alzheimer's disease
Biomarkers
Brief Communications
Diabetic retinopathy
Medical imaging
Parkinson's disease
Pathology
Retina
Software
Statistical analysis
Tomography
title The avascular zone and neuronal remodeling of the fovea in Parkinson disease
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