Policaptil Gel Retard significantly reduces body mass index and hyperinsulinism and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children and adolescents with family history of obesity and T2DM

Treatments for childhood obesity are critically needed because of the risk of developing co-morbidities, although the interventions are frequently time-consuming, frustrating, difficult, and expensive. We conducted a longitudinal, randomised, clinical study, based on a per protocol analysis, on 133...

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Published in:Italian journal of pediatrics 2015-02, Vol.41 (1), p.10-10, Article 10
Main Authors: Stagi, Stefano, Lapi, Elisabetta, Seminara, Salvatore, Pelosi, Paola, Del Greco, Paolo, Capirchio, Laura, Strano, Massimo, Giglio, Sabrina, Chiarelli, Francesco, de Martino, Maurizio
Format: Article
Language:English
Subjects:
Adolescent
Child
Comorbidity
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - genetics
Female
Gels
Glycemic Index
Humans
Hyperinsulinism - prevention & control
Macromolecular Substances - therapeutic use
Male
Obesity - genetics
Pediatric Obesity - epidemiology
Polysaccharides - therapeutic use
Risk Factors
Treatment Outcome
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Summary:Treatments for childhood obesity are critically needed because of the risk of developing co-morbidities, although the interventions are frequently time-consuming, frustrating, difficult, and expensive. We conducted a longitudinal, randomised, clinical study, based on a per protocol analysis, on 133 obese children and adolescents (n = 69 males and 64 females; median age, 11.3 years) with family history of obesity and type 2 diabetes mellitus (T2DM). The patients were divided into three arms: Arm A (n = 53 patients), Arm B (n = 45 patients), and Arm C (n = 35 patients) patients were treated with a low-glycaemic-index (LGI) diet and Policaptil Gel Retard, only a LGI diet, or only an energy-restricted diet (ERD), respectively. The homeostasis model assessment of insulin resistance (HOMA-IR) and the Matsuda, insulinogenic and disposition indexes were calculated at T0 and after 1 year (T1). At T1, the BMI-SD scores were significantly reduced from 2.32 to 1.80 (p 
ISSN:1824-7288
1824-7288
DOI:10.1186/s13052-015-0109-7