Knee osteoarthritis radiographic progression and associations with pain and function prior to knee arthroplasty: a multicenter comparative cohort study

• Published in: Osteoarthritis and cartilage 2015-03, Vol.23 (3), p.391-396
• Main Authors: Riddle, D.L, Jiranek, W.A
• Format: Article
• Language: English
• Subjects: Aged; Arthroplasty; Arthroplasty, Replacement, Knee; Case-Control Studies; Cohort Studies; Disease Progression; Female; Function; Humans; Knee; Knee Joint - diagnostic imaging; Knee Joint - physiopathology; Male; Middle Aged; Osteoarthritis; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - physiopathology; Osteoarthritis, Knee - surgery; Pain; Pain - physiopathology; Pain Measurement; Radiography; Rheumatology; Severity of Illness Index
• ISSN: 1063-4584; 1522-9653
• DOI: 10.1016/j.joca.2014.12.013

Summary Objectives We determined the radiographic osteoarthritic worsening rate prior to knee arthroplasty (TKA) and whether this worsening was associated with worsening pain and function as compared to a non-surgical matched sample. Methods We used the Osteoarthritis Initiative 5-year datasets. Extent of knee OA 2 years prior to total knee arthroplasty (TKA) was matched to knees of persons who did not undergo TKA. Western Ontario and McMaster Universities Arthritis Index (WOMAC) Function and Knee injury and Osteoarthritis Outcome Score (KOOS) Pain scales were used to quantify functional deficit and functionally relevant pain respectively. A total of 167 persons with isolated TKA and 300 persons with matched symptomatic knee OA but no TKA were studied. Results During the 2 years prior to TKA, worsening by at least one Kellgren and Lawrence (KL) grade occurred in 27.4% (95% CI = 20.6–34.2) of the surgical knees compared to 6.6% (95% CI = 3.8–9.4) of matched non-surgical knees. Osteoarthritis radiographic progression was strongly associated with WOMAC Function and KOOS Pain worsening ( P