Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning

Previous studies have demonstrated that pine pollen can inhibit cerebral cortical cell apoptosis in mice with arsenic poisoning. The present study sought to detect the influence of pine pollen on apoptosis-related proteins. Immunohistochemistry, western blotting and enzyme-linked immunosorbent assay...

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Bibliographic Details
Published in:Neural regeneration research 2012-04, Vol.7 (12), p.896-899
Main Authors: Luo, Yanhong, Wei, Yaodong, Wang, Taizhong, Chen, Dongzhu, Lu, Tiansheng, Wu, Ruibo, Si, Keke
Format: Article
Language:English
Subjects:
Apoptosis
Arsenic
Arsenic content
Bax蛋白
Brain
Flow cytometry
Immunoglobulins
Kinases
Laboratory animals
Poisoning
Protein expression
Proteins
Research and Report: Traditional Chinese Medicine and Neuroregeneration
大脑皮层
小鼠
松花粉
相关蛋白表达
砷中毒
细胞凋亡
酶联免疫吸附法
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Summary:Previous studies have demonstrated that pine pollen can inhibit cerebral cortical cell apoptosis in mice with arsenic poisoning. The present study sought to detect the influence of pine pollen on apoptosis-related proteins. Immunohistochemistry, western blotting and enzyme-linked immunosorbent assays were used to measure the levels of apoptosis-related proteins in the cerebral cortex of mice with arsenic poisoning. Results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing Bax, Bcl-2 protein expression and increasing p53 protein expression.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.12.003