Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes

• Published in: Journal of bone and mineral research 2011-07, Vol.26 (7), p.1554-1560
• Main Authors: Divers, Jasmin, Register, Thomas C, Langefeld, Carl D, Wagenknecht, Lynne E, Bowden, Donald W, Carr, J Jeffrey, Hightower, R Caresse, Xu, Jianzhao, Hruska, Keith A, Freedman, Barry I
• Format: Article
• Language: English
• Subjects: African americans; Atherosclerosis; Biological and medical sciences; Black or African American; Bone Density - physiology; Bone mineral density; Calcified plaque; Calcinosis - complications; Calcinosis - physiopathology; Demography; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Middle Aged; Models, Biological; Osteoporosis; Plaque, Atherosclerotic - complications; Plaque, Atherosclerotic - diagnostic imaging; Plaque, Atherosclerotic - physiopathology; Skeleton and joints; Spine - diagnostic imaging; Spine - physiopathology; Tomography, X-Ray Computed; Vertebrates: osteoarticular system, musculoskeletal system
• ISSN: 0884-0431; 1523-4681
• DOI: 10.1002/jbmr.389

Inverse relationships have been reported between bone mineral density (BMD) and calcified atherosclerotic plaque (CP). This suggests these processes may be related. We examined relationships between BMD and CP in 753 African Americans with type 2 diabetes from 664 families, accounting for the effects of modifiable cardiovascular disease (CVD) risk factors. Association analyses were performed using generalized estimating equations (GEEs) to assess cross‐sectional relationships between computed tomography–determined measures of thoracic and lumbar vertebral volumetric BMD (vBMD) and CP in the coronary and carotid arteries and infrarenal aorta. Significant inverse associations were seen between thoracic and lumbar vBMD and CP in all three vascular beds in unadjusted analyses. A fully adjusted model accounting for age, sex, body mass index, systolic blood pressure, low‐density lipoprotein cholesterol, C‐reactive protein, hemoglobin A1c, smoking, and hormone‐replacement therapy revealed significant inverse associations between thoracic vBMD and CP in coronary and carotid arteries and aorta, whereas lumbar vBMD was associated with CP in coronary artery and aorta. Inverse associations exist between vertebral BMD and calcified atherosclerotic plaque in African‐American men and women with type 2 diabetes. This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes. © 2011 American Society for Bone and Mineral Research.