Significant Association between Serum Levels of Von Willebrand Factor (vWF) Antigen with Stages of Cirrhosis

Von Willebrand factor (vWF) is a mediator that increases endotoxemic medium like in cirrhosis. In this study we evaluated the association of serum VWF antigen (Ag) level with the stage of cirrhosis (according to Child-Pugh classification). We included 82 cirrhotic patients (Female/Male (F/M): 26/56)...

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Published in:The Eurasian journal of medicine 2015-02, Vol.47 (1), p.21-25
Main Authors: Yilmaz, Vural Taner, Dincer, Dinc, Avci, Ali Berkant, Cetinkaya, Ramazan
Format: Article
Language:English
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Summary:Von Willebrand factor (vWF) is a mediator that increases endotoxemic medium like in cirrhosis. In this study we evaluated the association of serum VWF antigen (Ag) level with the stage of cirrhosis (according to Child-Pugh classification). We included 82 cirrhotic patients (Female/Male (F/M): 26/56) and 86 healthy subjects (F/M: 44/42) in the study. Ages of the both groups of patients were not different (P= 0.095). We excluded possible other reasons that may cause VWF level increase. Diagnosis of cirrhosis was made on the basis of biopsy in 7 patients and with clinical and laboratory parameters in 75 patients. VWF Ag level was determined by immunoturbidimetric test. The stage of cirrhosis was defined with Child-Pugh classification. Data were analysed by using Statistical Package for the Social Sciences (SPSS) 10.0 software program. VWF Ag level was significantly higher in cirrhotic patients compared to control group (220±90 and 87±38, P
ISSN:1308-8734
1308-8742
DOI:10.5152/eajm.2014.0016