Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures

Gja1(Jrt)/+ mice carry a mutation in one allele of the gap junction protein α1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negative for Cx43 protein production of

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Bibliographic Details
Published in:Molecular biology of the cell 2015-03, Vol.26 (5), p.832-842
Main Authors: Zappitelli, Tanya, Chen, Frieda, Aubin, Jane E
Format: Article
Language:English
Subjects:
Adipogenesis
Animals
Biomarkers - metabolism
Bone and Bones - metabolism
Bone Diseases, Metabolic - genetics
Bone Marrow - metabolism
Bone Marrow - physiology
Bone Morphogenetic Protein 2 - genetics
Bone Morphogenetic Protein 2 - metabolism
Bone Morphogenetic Protein 4 - genetics
Bone Morphogenetic Protein 4 - metabolism
Connexin 43 - genetics
Male
Mice
Mice, Mutant Strains
Mutation
Osteoblasts - metabolism
Signal Transduction
Stromal Cells - metabolism
Up-Regulation
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Description
Summary:Gja1(Jrt)/+ mice carry a mutation in one allele of the gap junction protein α1 gene (Gja1), resulting in a G60S connexin 43 (Cx43) mutant protein that is dominant negative for Cx43 protein production of
ISSN:1059-1524
1939-4586
DOI:10.1091/mbc.E14-06-1136