Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice

Highlights • Feedback via GR maintains cellular homeostasis and promotes behavioral adaptation. • GR loss in both brain and pituitary results in neonatal death. • Pituitary GR is important in early postnatal development of HPA axis function. • Hypothalamic GR is more essential for maintaining HPA ax...

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Bibliographic Details
Published in:Frontiers in neuroendocrinology 2015-01, Vol.36, p.150-164
Main Authors: Laryea, Gloria, Muglia, Lisa, Arnett, Melinda, Muglia, Louis J
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone
Animals
Circadian regulation
Corticosterone
Corticotropin-releasing hormone
Endocrinology & Metabolism
Gene Targeting
Glucocorticoid receptor
Hypothalamic–pituitary–adrenal axis
Hypothalamo-Hypophyseal System - metabolism
Hypothalamus - metabolism
Metabolism
Mice
Paraventricular nucleus of the hypothalamus
Pituitary
Pituitary-Adrenal System - metabolism
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - metabolism
Stress
Stress, Physiological - physiology
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Summary:Highlights • Feedback via GR maintains cellular homeostasis and promotes behavioral adaptation. • GR loss in both brain and pituitary results in neonatal death. • Pituitary GR is important in early postnatal development of HPA axis function. • Hypothalamic GR is more essential for maintaining HPA axis activity in adulthood. • Impaired GR-mediated feedback is observed in psychiatric and metabolic disorders.
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2014.09.002