Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation

Highlights • Alcohol vapor inhalation after mild focal TBI impairs neurological recovery. • Alcohol exposure is associated with decreased locomotion and impaired object recognition. • Alcohol exposure exacerbates TBI-induced microglial activation and HMGB1 expression. • Enhanced neuroinflammatory ma...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.145-156
Main Authors: Teng, Sophie X, Katz, Paige S, Maxi, John K, Mayeux, Jacques P, Gilpin, Nicholas W, Molina, Patricia E
Format: Article
Language:English
Subjects:
Alcohol
Alcohol Drinking - immunology
Allergy and Immunology
Animals
Brain - drug effects
Brain - immunology
Brain - pathology
Brain Injuries - immunology
Brain Injuries - physiopathology
Central Nervous System Depressants - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - immunology
Cerebral Cortex - injuries
Cerebral Cortex - pathology
Ectodysplasins - drug effects
Ectodysplasins - immunology
Ethanol - pharmacology
Exploratory Behavior - drug effects
Exploratory Behavior - physiology
Glial Fibrillary Acidic Protein - drug effects
Glial Fibrillary Acidic Protein - immunology
HMGB1 Protein - drug effects
HMGB1 Protein - immunology
Inflammation
Neurobehavior
Neuroinflammation
Psychiatry
Rats
Rats, Sprague-Dawley
Recognition, Psychology - drug effects
Recognition, Psychology - physiology
Recovery of Function - drug effects
Trauma Severity Indices
Traumatic brain injury
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Summary:Highlights • Alcohol vapor inhalation after mild focal TBI impairs neurological recovery. • Alcohol exposure is associated with decreased locomotion and impaired object recognition. • Alcohol exposure exacerbates TBI-induced microglial activation and HMGB1 expression. • Enhanced neuroinflammatory markers are linked to impaired neurological recovery.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2014.11.006