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Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation

Highlights • Alcohol vapor inhalation after mild focal TBI impairs neurological recovery. • Alcohol exposure is associated with decreased locomotion and impaired object recognition. • Alcohol exposure exacerbates TBI-induced microglial activation and HMGB1 expression. • Enhanced neuroinflammatory ma...

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Published in:	Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.145-156
Main Authors:	Teng, Sophie X, Katz, Paige S, Maxi, John K, Mayeux, Jacques P, Gilpin, Nicholas W, Molina, Patricia E
Format:	Article
Language:	English
Subjects:	Alcohol Alcohol Drinking - immunology Allergy and Immunology Animals Brain - drug effects Brain - immunology Brain - pathology Brain Injuries - immunology Brain Injuries - physiopathology Central Nervous System Depressants - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - immunology Cerebral Cortex - injuries Cerebral Cortex - pathology Ectodysplasins - drug effects Ectodysplasins - immunology Ethanol - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Glial Fibrillary Acidic Protein - drug effects Glial Fibrillary Acidic Protein - immunology HMGB1 Protein - drug effects HMGB1 Protein - immunology Inflammation Neurobehavior Neuroinflammation Psychiatry Rats Rats, Sprague-Dawley Recognition, Psychology - drug effects Recognition, Psychology - physiology Recovery of Function - drug effects Trauma Severity Indices Traumatic brain injury
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description	Highlights • Alcohol vapor inhalation after mild focal TBI impairs neurological recovery. • Alcohol exposure is associated with decreased locomotion and impaired object recognition. • Alcohol exposure exacerbates TBI-induced microglial activation and HMGB1 expression. • Enhanced neuroinflammatory markers are linked to impaired neurological recovery.
doi_str_mv	10.1016/j.bbi.2014.11.006
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subjects	Alcohol Alcohol Drinking - immunology Allergy and Immunology Animals Brain - drug effects Brain - immunology Brain - pathology Brain Injuries - immunology Brain Injuries - physiopathology Central Nervous System Depressants - pharmacology Cerebral Cortex - drug effects Cerebral Cortex - immunology Cerebral Cortex - injuries Cerebral Cortex - pathology Ectodysplasins - drug effects Ectodysplasins - immunology Ethanol - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Glial Fibrillary Acidic Protein - drug effects Glial Fibrillary Acidic Protein - immunology HMGB1 Protein - drug effects HMGB1 Protein - immunology Inflammation Neurobehavior Neuroinflammation Psychiatry Rats Rats, Sprague-Dawley Recognition, Psychology - drug effects Recognition, Psychology - physiology Recovery of Function - drug effects Trauma Severity Indices Traumatic brain injury
title	Alcohol exposure after mild focal traumatic brain injury impairs neurological recovery and exacerbates localized neuroinflammation
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