Behavioral and emotional dysregulation trajectories marked by prefrontal–amygdala function in symptomatic youth

Neuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dys...

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Bibliographic Details
Published in:Psychological medicine 2014-09, Vol.44 (12), p.2603-2615
Main Authors: Bertocci, M. A., Bebko, G., Olino, T., Fournier, J., Hinze, A. K., Bonar, L., Almeida, J. R. C., Perlman, S. B., Versace, A., Travis, M., Gill, M. K., Demeter, C., Diwadkar, V. A., White, R., Schirda, C., Sunshine, J. L., Arnold, L. E., Holland, S. K., Kowatch, R. A., Birmaher, B., Axelson, D., Youngstrom, E. A., Findling, R. L., Horwitz, S. M., Fristad, M. A., Phillips, M. L.
Format: Article
Language:English
Subjects:
Adolescent
Adolescent Development - physiology
Affective Symptoms - physiopathology
Amygdala - physiopathology
Behavior disorders
Behavioral Symptoms - physiopathology
Biological and medical sciences
Biomarkers
Brain
Child
Child development
Cortex
Emotional disorders
Emotional regulation
Female
Functional connectivity
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Medical imaging
Medical sciences
Neuroimaging
Original Articles
Parents
Prefrontal Cortex - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Young people
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Summary:Neuroimaging measures of behavioral and emotional dysregulation can yield biomarkers denoting developmental trajectories of psychiatric pathology in youth. We aimed to identify functional abnormalities in emotion regulation (ER) neural circuitry associated with different behavioral and emotional dysregulation trajectories using latent class growth analysis (LCGA) and neuroimaging. A total of 61 youth (9-17 years) from the Longitudinal Assessment of Manic Symptoms study, and 24 healthy control youth, completed an emotional face n-back ER task during scanning. LCGA was performed on 12 biannual reports completed over 5 years of the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M), a parental report of the child's difficulty regulating positive mood and energy. There were two latent classes of PGBI-10M trajectories: high and decreasing (HighD; n=22) and low and decreasing (LowD; n=39) course of behavioral and emotional dysregulation over the 12 time points. Task performance was >89% in all youth, but more accurate in healthy controls and LowD versus HighD (p
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291714000087