PCDH20 functions as a tumour-suppressor gene through antagonizing the Wnt/β-catenin signalling pathway in hepatocellular carcinoma

Summary Several members of protocadherins have been found involved in human carcinogenesis, but little is known about PCDH20 in HCC. Here in this study, using quantitative real‐time RT‐PCR assay, we demonstrated the downregulation of PCDH20 expression in 6 of 7 HCC cell lines tested. Similarly, PCDH...

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Bibliographic Details
Published in:Journal of viral hepatitis 2015-02, Vol.22 (2), p.201-211
Main Authors: Lv, J., Zhu, P., Yang, Z., Li, M., Zhang, X., Cheng, J., Chen, X., Lu, F.
Format: Article
Language:English
Subjects:
Adult
Aged
Cadherins - genetics
Cadherins - metabolism
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
Down-Regulation
Gene Expression Profiling
Genes, Tumor Suppressor
hepatocellular carcinoma
Humans
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
methylation
Middle Aged
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Original
PCDH20
tumour-suppressor gene
Wnt Signaling Pathway - physiology
Wnt/β-catenin signalling pathway
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Summary:Summary Several members of protocadherins have been found involved in human carcinogenesis, but little is known about PCDH20 in HCC. Here in this study, using quantitative real‐time RT‐PCR assay, we demonstrated the downregulation of PCDH20 expression in 6 of 7 HCC cell lines tested. Similarly, PCDH20 expression in primary HCC tissues was also significantly downregulated in comparison with that in either disease‐free normal liver tissues or the adjacent nontumour liver tissues (P 
ISSN:1352-0504
1365-2893
DOI:10.1111/jvh.12265