RISUG: an intravasal injectable male contraceptive

Over the last two decades RISUG has been drawing attention in the field of male contraception. It promises to sterile men for a period of up to 10-15 years. According to recent studies in animal models, it proves to be completely reversible. Practically, there are no better options available that ca...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2014-11, Vol.140 Suppl (Suppl 7), p.S63-S72
Main Authors: Lohiya, N K, Alam, I, Hussain, M, Khan, S R, Ansari, A S
Format: Article
Language:English
Subjects:
Clinical Trials as Topic
Contraception - economics
Contraception - methods
Contraceptive Agents, Male - administration & dosage
Contraceptive Agents, Male - pharmacology
Dimethyl Sulfoxide - metabolism
Humans
Injections
Innovations
Male
Male contraceptives
Maleic Anhydrides - metabolism
Review
Styrene - metabolism
Vas Deferens - metabolism
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Summary:Over the last two decades RISUG has been drawing attention in the field of male contraception. It promises to sterile men for a period of up to 10-15 years. According to recent studies in animal models, it proves to be completely reversible. Practically, there are no better options available that can assure complete sterility and precise reversibility. Regardless of so much of information available, RISUG is still holding up for many reasons, firstly, the available information engender bewilderment such as what is this copolymer, how does it work and is reversal really possible? Secondly, advancement of this outstanding invention is drastically slow and thirdly, effects of long-term contraception with RISUG and reports on evaluation of anomalies (if any) in F 1 , F 2 progenies, are lacking. In this review the lacunae as well as advances in the development of RISUG in the light of published work and available resources are pointed out. Formulation of the RISUG, its mode of action and clinical trials have been addressed with particular emphasis.
ISSN:0971-5916
0975-9174