Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue

• Published in: Particle and fibre toxicology 2014-12, Vol.11 (1), p.63, Article 63
• Main Authors: Savi, Monia, Rossi, Stefano, Bocchi, Leonardo, Gennaccaro, Laura, Cacciani, Francesca, Perotti, Alessio, Amidani, Davide, Alinovi, Rossella, Goldoni, Matteo, Aliatis, Irene, Lottici, Pier Paolo, Bersani, Danilo, Campanini, Marco, Pinelli, Silvana, Petyx, Marta, Frati, Caterina, Gervasi, Andrea, Urbanek, Konrad, Quaini, Federico, Buschini, Annamaria, Stilli, Donatella, Rivetti, Claudio, Macchi, Emilio, Mutti, Antonio, Miragoli, Michele, Zaniboni, Massimiliano
• Format: Article
• Language: English
• Subjects: Action Potentials - drug effects; Air Pollutants - toxicity; Animals; Arrhythmias, Cardiac - chemically induced; Arrhythmias, Cardiac - physiopathology; Cell Membrane Permeability - drug effects; Cells, Cultured; Computer Simulation; DNA Damage; Excitation Contraction Coupling - drug effects; Health aspects; Heart; Heart Conduction System - drug effects; Heart Conduction System - physiopathology; Heart Ventricles - cytology; Heart Ventricles - drug effects; Heart Ventricles - physiopathology; Heart Ventricles - ultrastructure; Inhalation Exposure - adverse effects; Lipid Peroxidation - drug effects; Male; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - toxicity; Models, Biological; Myocytes, Cardiac - cytology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - ultrastructure; Pollution; Rats, Wistar; Titanium - administration & dosage; Titanium - toxicity; Toxicity Tests, Acute
• ISSN: 1743-8977; 1743-8977
• DOI: 10.1186/s12989-014-0063-3

In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction of nanoparticles with body tissues, in particular within the cardiovascular system. Attention has recently focused on the link between environmental pollution and cardiovascular diseases. Nanoparticles