Microneedles for Drug Delivery via the Gastrointestinal Tract

Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well as general pH variability from pH 1 to 7. These extreme environments make ora...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2015-02, Vol.104 (2), p.362-367
Main Authors: Traverso, Giovanni, Schoellhammer, Carl M., Schroeder, Avi, Maa, Ruby, Lauwers, Gregory Y., Polat, Baris E., Anderson, Daniel G., Blankschtein, Daniel, Langer, Robert
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological Availability
Biological Products - administration & dosage
drug delivery systems
Drug Delivery Systems - methods
Equipment Design
gastrointestinal
Gastrointestinal Tract - physiology
Humans
Insulin - administration & dosage
macromolecular drug delivery
membrane transport
Microinjections - instrumentation
microneedles
mucosal drug delivery
Needles
oral drug delivery
pill
Software
Swine
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Summary:Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well as general pH variability from pH 1 to 7. These extreme environments make oral delivery particularly challenging for the biologic class of therapeutics. Here, we demonstrate proof-of-concept experiments in swine that microneedle-based delivery has the capacity for improved bioavailability of a biologically active macromolecule. Moreover, we show that microneedle-containing devices can be passed and excreted from the GI tract safely. These findings strongly support the success of implementation of microneedle technology for use in the GI tract. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:362–367, 2015
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.24182