Naturally-acquired dengue virus infections do not reduce short-term survival of infected Aedes aegypti from Ho Chi Minh City, Vietnam

Transmission of dengue virus (DENV) from mosquito to human is dependent upon the survival of the mosquito beyond the virus extrinsic incubation period. Previous studies report conflicting results of the effects of DENV on Aedes aegypti survival. Here, we describe the effect of DENV on the short-term...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2015-03, Vol.92 (3), p.492-496
Main Authors: Carrington, Lauren B, Nguyen, Hoa L, Nguyen, Nguyet Minh, Duong, T H Kien, Tuan, Trung Vu, Giang, Nguyen Thi, Tuyet, Nhu Vu, Thi, Dui Le, Thi, Long Vo, Tran, Chau N, Simmons, Cameron P
Format: Article
Language:English
Subjects:
Aedes - physiology
Aedes - virology
Aedes aegypti
Animals
Dengue - epidemiology
Dengue - transmission
Dengue virus
Dengue Virus - physiology
Host-Parasite Interactions
Humans
Insect Vectors - virology
Longevity
Vietnam - epidemiology
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Summary:Transmission of dengue virus (DENV) from mosquito to human is dependent upon the survival of the mosquito beyond the virus extrinsic incubation period. Previous studies report conflicting results of the effects of DENV on Aedes aegypti survival. Here, we describe the effect of DENV on the short-term survival (up to 12 d) of 4,321 Ae. aegypti mosquitoes blood-fed on 150 NS1-positive dengue patients hospitalized in the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Mosquito survival was not different between cohorts that fed upon blood from which 0% of mosquitoes became DENV infected (N = 88 feeds), or 100% became infected (N = 116 feeds). Subgroup analysis also did not reveal serotype-dependent differences in survival, nor a relationship between survival and human plasma viremia levels. These results suggest that DENV infection adds minimal cost to Ae. aegypti, an important finding when parameterizing the vector competence of this mosquito.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.14-0499