T2 measurement of the knee articular cartilage in osteoarthritis at 3T

Purpose: To measure reproducibility, longitudinal and cross‐sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls. Materials and Methods: MRI data and standing radiographs were acquired from 33 subjec...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance imaging 2012-06, Vol.35 (6), p.1422-1429
Main Authors: Newbould, Rexford D., Miller, Sam R., Toms, Laurence D., Swann, Peter, Tielbeek, Jeroen A.W., Gold, Garry E., Strachan, Robin K., Taylor, Peter C., Matthews, Paul M., Brown, Andrew P.
Format: Article
Language:English
Subjects:
cartilage
Cartilage, Articular - pathology
Female
Humans
Knee Joint - pathology
Magnetic Resonance Imaging - methods
Male
Middle Aged
MRI
osteoarthritis
Osteoarthritis, Knee - pathology
Reproducibility of Results
Sensitivity and Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To measure reproducibility, longitudinal and cross‐sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls. Materials and Methods: MRI data and standing radiographs were acquired from 33 subjects with OA and 21 healthy controls matched for age and gender. Reproducibility was determined by two sessions in the same day, while longitudinal and cross‐sectional group differences used visits at baseline, 3 and 6 months. Each visit contained symptomological assessments and an MRI session consisting of high resolution three‐dimensional double‐echo‐steady‐state (DESS) and co‐registered T2* maps of the most diseased knee. A blinded reader delineated the articular cartilage on the DESS images and median T2* values were reported. Results: T2* values showed an intra‐visit reproducibility of 2.0% over the whole cartilage. No longitudinal effects were measured in either group over 6 months. T2* maps revealed a 5.8% longer T2* in the medial tibial cartilage and 7.6% and 6.5% shorter T2* in the patellar and lateral tibial cartilage, respectively, in OA subjects versus controls (P < 0.02). Conclusion: T2* mapping is a repeatable process that showed differences between the OA subject and control groups. J. Magn. Reson. Imaging 2012;35:1422–1429. © 2012 Wiley Periodicals Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.23598